Muscadines are one of nature’s richest sources of polyphenolic antioxidants.

Source: The Journal of Agricultural and Food Chemistry 51(18):5497-503

What are “Polyphenolic Antioxidants”? (Resveratrol, Quercetin)

We’re glad you asked! The Miriam-Webster dictionary definitions follow:

  • A “Polyphenol” as an antioxidant phytochemical.
  • “Phytochemistry” is the chemistry of plants, plant processes, and plant products.
  • An “Antioxidant” is a substance that inhibits oxidation or reactions promoted by oxygen, peroxides, or free radicals.

So basically, polyphenolic antioxidants are naturally occurring, healthful, compounds found in plants, and are especially abundant in the humble, but amazing, muscadine grape (vitis rotundifolia). These antioxidant compounds are like little superheros working together (synergistically) to fight free radical damage to our bodies.

The power of antioxidants in muscadines help protect the body from damaging effects of oxygen free radicals, which can contribute to degenerative disease.  Source: College of Agriculture and Life Sciences, NC State University, Raleigh, NC.

Muscadines 101

Muscadines (Vitis rotundifolia) are Native to the southeastern United States.  Muscadines are the smarter grape with 20 sets of chromosomes, rather than table and wine grapes (Vitis vinefera) that have 19 sets.  The extra set of chromosomes gives muscadines a thick skin to protect the fruit and a thick hull to protect the seed.  The seeds and skins are where the majority of the phytonutrients are found.  Muscadine juice averages 14% sugar content while regular grape juice averages 26% sugar content.  For more information check out Wikipedia.

Research Sources

Many authoritative resources exist that document the health benefits of muscadines.  Dr. Diane Hartle, who recently retired as a professor of the University of Georgia’s School of Pharmacy, has studied and taught the health benefits of muscadines for many years.  She has graciously allowed us to offer her book, “Muscadine Health“.  She is the leading authority on the health benefits of muscadines.  We strongly encourage you to read this book.

The National Center for Biotechnology Information, National Library of Medicines, and National Institutes of Health have a terrific resource, known as PubMed.  PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books.

Very recent news stories on Polyphenols:

Scientific studies suggest the compounds in muscadines may help us in many ways:

What are the exact phytonutrients that help us?

  • Ellagic Acid
  • Myricetin
  • Quercetin
  • Kaempferol
  • Resveratrol
  • Gallic Acid
  • Catechin
  • Anthocyanins
  • Caffeic Acid
  • Proanthocyanins
  • (-) -Epicatechin
  • Cholorgenic Acid

Don’t worry about the pronunciations; you will not be tested on this. All you really need to remember is that the muscadine grape packs a powerful, all natural punch in the quest for healthy living!


Resveratrol is one of 88 known active compounds in Muscadine Grapes. Resveratrol occurs naturally in certain fruits and activates the Sirtuin enzymes, which have shown therapeutic potential for age-related health problems.  A compound (C14 H12 O3) that is a trihydroxy trans form of stilbene.  Naturally occuring in muscadines, resveratrol activates our genes for a longer, healthier life.

A Muscadine Superstar, Resveratrol


Another superstar phytonutrient in muscadines is Quercetin, a compound (C15 H10 O15) which is a 3 ring, 5 hydoxyl group flavenoid.  Naturally occuring in muscadines, big Q helps protect DNA and has been studied for many health issues. What does the American Cancer Society say about Quercetin?

Quercetin molecule, a Superstar Phytonutrient


Please note that we are not making any specific health claims about our products. Everyone has different lifestyles and DNA which interact with the phytonutrients in muscadines differently.  We only invite you to learn more and discover for yourself.  We have received many testimonials and are very careful about telling the story authentically and truthfully.

Statements made about muscadine products have not been evaluated by the FDA. Academic scientists, researchers, and all of us at The MotherVine advise you to consult your physician or other health care provider prior to making any decisions, or undertaking any actions, or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future.